Assessment Of Polyalthia Longifolia Var. Pendula For Hypoglycemic And Antihyperglycemic Activity
NAIR R, SHUKLA V, CHANDA S
Corresponding Author Chanda S
Phytochemical, Pharmacological and Microbiological Laboratory,
Department of Biosciences, Saurashtra University, Rajkot-360 005, Gujarat, India
The hypoglycemic and antihyperglycemic activity of various solvent extracts of Polyalthia longifolia var. pendula leaf extracts was evaluated in alloxan induced experimental diabetes in rats. Diabetes was induced using 180 mg/kg i.p. of alloxan consecutively two times at an interval of 24 h. The test drugs were administered for 7 days. On 8th day various biochemical parameters like serum cholesterol, serum urea, serum creatinine, serum triglyceride, total serum protein, serum alkaline phosphatase, blood glucose and glycogen from liver were estimated. Polyalthia longifolia extracts and powder produced glucose lowering activity. However, the extracts did not modify any of the biochemical parameter significantly. Hence the extracts and crude powder are devoid of anti-diabetic properties, but has gross glucose lowering properties. The presence of anti-hyperglycemic effect against sucrose loading induced hyperglycemia is a significant finding. Now-a-days, it is considered that this effect is most important property in a drug used in diabetes treatment.
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